NOTAS DE ENDODONCIA
APOYO ACADÉMICO
POR ANTOLOGÍAS
UNIDAD
6: EMBRIOLOGÍA, HISTOLOGÍA Y FISIOLOGÍA PULPAR
Profesor:
Dr.
Ricardo Rivas Muñoz
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CONTENIDO
DE TODA LA UNIDAD 6:
6.1. Embriología dental
6.1.1. Generalidades
6.1.2. Etapas del desarrollo
6.1.2. Desarrollo de las estructuras radiculares
6.1.3. Conductos laterales y forámenes accesorios
6.1.4. Anomalías en el desarrollo dental
6.1.4.1. Neoplasias
6.1.4.2. Infecciones
6.1.4.3. Traumatismos
6.1.4.4. Trastornos nutricionales
6.1.4.5. Defectos congénitos
6.1.4.6. Efectos de medicamentos
6.2. Fisiología pulpar
6.2.1. Función formativa
6.2.2. Función nutritiva
6.2.2.1. Circulación arterial
6.2.2.2. Circulación venosa
6.2.2.3. Drenaje linfático
6.2.3. Función nerviosa
6.2.3.1. Inervación pulpar
6.2.3.2. Dolor dental y pulpar
6.2.3.2.1. Mecanismos periféricos del dolor
6.2.3.2.2. Teorías sobre la percepción del dolor dental
6.3. Anatomía topográfica de la cavidad pulpar
6.3.1. Nomenclatura de Pucci y Reig
6.3.2. Nomenclatura de Ardines
6.3.3. Topografía pulpar según Kuttler
6.3.4. Medidas promedio de los dientes permanentes
6.4. La dentina
6.5. Tejido conectivo
6.5.1. Fibras
6.5.2. Células
6.5.3. Substancia fundamental
6.6. La pulpa dental
6.6.1. Capas de la pulpa
6.6.1.1. Capa odontoblástica
6.6.1.2. Zona de Weil
6.6.1.3. Zona rica en células
6.6.1.4. Estroma pulpar
6.6.2. Tercio apical
6.6.2.1. Tejido pulpar apical
6.6.2.2. Dentina apical
6.6.2.3. Dentículos y calcificaciones distróficas
6.6.2.4. Unión cemento dentina conducto
6.7. Células de la pulpa
6.7.1. Odontoblastos
6.7.2. Fibroblastos
6.7.3. Otras células |
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PALABRAS
CLAVE |
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REGRESAR A LA SECCIÓN SOBRE DENTINA
Y PULPA DENTAL
RESUMEN DEL ARTÍCULO CITADO
ABSTRACT
Matrix
Metalloproteinase-2 in Dentin Matrix Mineralization
Masanori Satoyoshi DDS,
PhD, Akira Kawata DDS, PhD, Tadahiko Koizumi DDS, PhD, Keiichi Inoue MS,
Shigeyoshi Itohara DVM, PhD, Toshio Teranaka DDS, PhD and Yuko Mikuni-Takagaki
PhD
In the serum-free culture
medium of bovine odontoblasts
we detected active gelatinolytic metalloproteinases, matrix metalloproteinase (MMP)-2
and MMP-9 (gelatinases A and B). The activity of MMP-2, in particular, appeared
suddenly around day 21 in the culture, coinciding with the development of
odontoblastic cell processes and the loss of alkaline phosphatase. Reverse
transcriptase-polymerase chain reaction analysis of these
odontoblasts
demonstrated that messages of MMP-2 but not MMP-9 increased significantly
between day 15 and day 21. The in vitro observation indicates that medium
conditioned by these
odontoblasts
and containing significant amounts of MMP-2 degrades not only the collagenous
substrates but also purified dentin phosphophoryn as well. We have also observed
that dephosphorylated dentin phosphoprotein becomes a better substrate for
casein kinase II after limited proteolysis with MMP-2. These results support our
working hypothesis that MMP-2-mediated proteolytic processing is an important
step in accelerating the process of dentin matrix maturation, which includes
phosphorylation and subsequent mineralization. As has been suggested previously,
extracellular phosphorylation of matrix proteins is an important step in
biomineralization both in bone and in dentin (Mikuni-Takagaki et al., J Bone
Miner Res 1995;10:231–42; Zhu et al., Biochem J 1997;323:637–43). Our
present histochemical analysis in MMP-2 knockout mice confirms the concept with
the delayed formation of mineralized tissues, dentin, and bone
Satoyoshi, Masanori.
Matrix
Metalloproteinase-2 in Dentin Matrix Mineralization,
JOE. jul
2001;27(7):462-466.
Investigado por Florina Santiago
Vasconcelos, Alumna del grupo 2632 (2008), FES Iztacala, UNAM
