SECTION 1. THE INFECTION

Introduction to Section 1.

Chapter 1.
Endodontic infections and the etiology of apical periodontitis - an overview.
José F Siqueira Jr.

- Apical periodontitis: an infectious disease
- Routes of endodontic infection
- Types of endodontic infections

Chapter 2.
The invaders. Bacterial biofilm communities and pathogenicity
José F.Siqueira Jr., Isabela N. Rôças

- Teamwork is what counts - community as pathogen
- Mechanisms of bacterial pathogenicity
- Virulence factors

Chapter 3.
The defense: host-pathogen interactions and inmune response.
José F.Siqueira Jr.

- Host defenses against bacteria - an overview
- Innate immunity
- Adaptive immunity
- Bone resorption and the immune response

Chapter 4.
The disease: Clinical manifestations and pathophysiology
José F. Siqueira Jr.

- Pulp response to infection
- Apical periodontitis
- The acute periraducular response
- Symptomatic apical periodontitis
- Acute apical abscess
- The chronic periradicular response
- Asymptomatic apical periodontitis
- Chronic apical abscess (suppurative chronic apical periodontitis)

Chapter 5.
Primary endodontic infections.
José F.Siqueira Jr., Isabela N. Rôças

- Bacterial diversity in primary infections
- Anatomy of infection - spatial distribution
- Bacterial ecology and the root canal ecosystem
- Other microorganisms in endodontic infections

Chapter 6.
Persistent and secondary endodontic infections
José F.Siqueira Jr., Isabela N. Rôças

- Secondary infection - a contamination issue
- Persistent/secondary infections and treatment failure

Chapter 7.
Causes of endodontic treatment failure
José F.Siqueira Jr., Isabela N. Rôças

- Microbial causes of endodontic failure
- Non-microbial causes of endodontic failure
- Failure after periradicular surgery
- Concluding remarks

Chapter 8.
Causes of persistent post-treatment pain in endodontics
José F.Siqueira Jr.

- The problem of post-treatment pain
- Causes of post-treatment pain
- Concluding remarks

Chapter 9.
Systemic implications of endodontic infections
José F.Siqueira Jr.

- From here to there: systemic effects of endodontic infections
- From here to there: effects of systemic conditions on apical periodontitis

Plate
Endodontic microbiota in different clinical conditions

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SECTION 2 - THE TREATMENT

Introduction to Section 2

Chapter 10.
Preventing endodontic infections
José F.Siqueira Jr., Isabela N. Rôças

Chapter 11.
Controling endodontic infections - an overview
José F.Siqueira Jr., Isabela N. Rôças

- Treating infected root canals
- One-visit versus two-visit treatment
- Effects of treatment - results of molecular methods
- Ecological considerations
- Clinical protocol - recommendations

Chapter 12.
Chemomechanical preparation
José F.Siqueira Jr., Hélio P. Lopes

- Objetives
- Kinetics of endodontic instruments
- Apical limit of preparation
- When preparation is complete
- Irrigation
- Techniques for root canal preparation
- Smear layer

Chapter 13.
Intracanal medication
José F.Siqueira Jr.

- Indications for occasional intracanal medication
- Indications for routine intracanal medication
- Calcium hydroxide
- Clinical recommendations
- Optimizing single-visit disinfection
- Concluding remarks

Chapter 14.
Obturation of the root canal system
José F.Siqueira Jr.

- Objectives
- Timing of obturation

Chapter 15.
Treating failures: retreatment and periradicular surgery
José F.Siqueira Jr.

Chapter 16.
Endodontic emergencies of infectious origin
José F.Siqueira Jr.

Chapter 17.
Systemic antibiotics in endodontics
José F.Siqueira Jr.

Index

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